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腫瘤基因組捕獲測序

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腫瘤基因組捕獲測序

產品簡介:

        邁基諾腫瘤領域的服務內容主要分為遺傳性腫瘤檢測和常見腫瘤的治療、預后、復發監測。其中,腫瘤驅動基因檢測、循環腫瘤DNA(ctDNA)是邁基諾科研服務的重點內容。

1.驅動基因

        研究證明,人類癌癥是由致癌基因和抑癌基因突變積累造成的。多數的基因突變都是沒有功能或不是致病的突變;少部分基因突變具有致癌功能,是大部分腫瘤都共有的突變,叫做“Driver Mutation”。這一類型的突變是導致腫瘤發生的主要原因,突變所在的基因又稱腫瘤驅動基因。腫瘤突變及其發病機制的研究應當首先集中在腫瘤驅動基因上。

        邁基諾公司自主研發的一系列“OncoCap”腫瘤驅動基因捕獲試劑盒,包括高頻腫瘤驅動基因,重要腫瘤信號通路相關基因(RTK-RAS-RAF,PI3K-AKT-mTOR,Cell Cycle,P53_DNA repair)和重要的由于擴增或缺失致癌的驅動基因等,同時,公司也提供個性化定制腫瘤驅動基因捕獲試劑盒,廣泛應用于腫瘤用藥研究,預后及分子病理研究,為腫瘤科研和臨床工作者全面系統的研究腫瘤的發生和演變機制提供了有效工具。邁基諾的驅動基因檢測覆蓋組織樣本、血液樣本,根據不同樣本類型采取不同的測序策略。

 

  組織樣本 血液樣本
測序深度 500~1000X 50000~100000X
測序靈敏度 0.5% 0.05%

2.循環腫瘤DNA(ctDNA)

        ctDNA,即循環腫瘤DNA,指由腫瘤細胞釋放到血液循環系統中的DNA。ctDNA具有含量少、片段小、半衰期短等特點。ctDNA的含量與腫瘤大小、分期等病理特征相關,并且攜帶著腫瘤細胞基因突變的序列信息。因此,對血漿、其他體液亦或某些分泌物中ctDNA進行檢測已被越來越廣泛地用于腫瘤篩查、病程監控、治療效果評價等方面,其做為液體活檢技術的代表被視為未來腫瘤檢測的新趨勢,具有安全、快捷、便利、靈敏度高等諸多優勢,為腫瘤的病因、治療、預后監測等提供了科學方法和高效工具。

產品列表

“OncoCap”系列腫瘤驅動基因捕獲試劑盒:
OncoCap_48試劑盒
OncoCap_265試劑盒
OncoCap_30fuse試劑盒
OncoCap_725試劑盒
個性化訂制腫瘤驅動基因捕獲試劑盒;
腫瘤ctDNA解決方案


生物信息分析:

 
標準化分析 SNP/SNV;InDel;CNV/CNA; SV;Gene Mutation Frequency
個性化分析 Fusion Gene;Mutation Spectrum;Pathway Enrichment;
Chi-square Test;  Fisher’s Exact Test;Circos Map; 
Cancer Somatic Cell Mutation
 
測序策略:PE150

項目周期:30個工作日——捕獲測序(自樣本質控合格之日起,不包括數據分析),附加5~15個工作日進行數據分析。

 

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